[Download] "Tumor-Associated Trypsin Inhibitor." by Clinical Chemistry # Book PDF Kindle ePub Free
eBook details
- Title: Tumor-Associated Trypsin Inhibitor.
- Author : Clinical Chemistry
- Release Date : January 01, 2002
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 157 KB
Description
Tumor-associated trypsin inhibitor (TATI) [1] was initially isolated from the urine of a patient with ovarian cancer (1). TATI is a peptide produced at high concentrations by mucinous ovarian tumors, but it is expressed by several other tumors. TATI is identical to the earlier described pancreatic secretory trypsin inhibitor (PSTI) (2), which also is called the Kazal inhibitor (3). Clinically, TATI is most useful for monitoring of patients with mucinous ovarian cancer, but increased serum concentrations of TATI may occur in most types of cancer. In ovarian, bladder, and kidney cancer, TATI is a marker of adverse prognosis. This appears to be explained by the coexpression of TATI and tumor-associated trypsin, which is thought to participate in tumor-associated protease cascades mediating tumor invasion (4). Structure, Expression, and Function